Abstract
AbstractIsoxazolidines and 1,3‐aminoalcohols with a piperazin‐2‐one skeleton were readily prepared on a solid support through [3+2] cycloaddition and subsequent N−O‐bond cleavage, starting from a polymer‐supported cyclic nitrone. Libraries of functionalized 1,3‐aminoalcohols and their derivatives were obtained by automated amine acylation and Mitsunobu reactions on a solid support. The key to success is the oxidation of the immobilized cyclic secondary amine precursor to the nitrone on a solid support and the reductive N−O‐bond cleavage of the isoxazolidines, employing Mo(CO)6. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
