Abstract
An efficient 2‐oxo‐group‐promoted direct coupling reaction between 2‐oxo aldehydes and hydroperoxides has been developed. The method has been used successfully for the generation of different 2‐oxo esters and acids. This reaction harnesses the hydrogen‐bonding‐induced self‐decomposition tendency of hydroperoxides; the intermediates produced by this process then attack the aldehyde or iminium ion to generate cross‐coupled products either by direct coupling or by an amine‐catalysed pathway. No external oxidants or metal catalysts are required for our method, and the reaction takes place at room temperature.
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