Abstract
Recently, HER3 has received attention as new anti-HER3 antibody-drug conjugates (e.g. U3-1402) are showing activity in BC. The most common method to determine HER3 expression is immunohistochemistry (IHC)-based assays. However, technical limitations exist when using IHC, such as different sensitivities of the antibodies and its subjectivity in scoring and cut-off determination. To overcome those limitations, we developed an mRNA-based ERBB3 expression assay using FFPE BC tissues and the Nanostring nCounter platform.
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