Abstract
The effect of 2-mercapto-1-(β-4-pyridethyl) benzimidazole (MPB) was determined in fetal rat liver explants. MPB exerted little effect upon the uptake of 14C-labeled orotic acid by the fetal liver, but exerted a very pronounced inhibition of the incorporation of the precursor into TCA-insoluble, alkalilabile material. These studies justify in fetal rat liver systems the use of MPB as an inhibitor of RNA synthesis unmediated by permeability effects.
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