Abstract

[32751-01-2] C3H2F6O3 (MW 200.05) InChI = 1S/C3H2F6O3/c4-2(5,6)1(10,12-11)3(7,8)9/h10-11H InChIKey = HIQGIIMAEPEBRI-UHFFFAOYSA-N (oxidizing agent capable of Baeyer–Villiger oxidation;1 selective alkene epoxidation;2 conversion of aldehydes to carboxylic acids;3 N-, S-, Se-oxidation;4 strong parallels in structure and function to biologically active flavin oxidants5-7) Alternate Name: HPHP. Physical Data: liquid at rt. Solubility: sol CH2Cl2. Preparative Method: prepared by the reaction of hexafluoroacetone (HFA)8 with either 30% or 90% Hydrogen Peroxide by the following representative procedure. A 250 mL roundbottomed flask is fitted with Claisen adapter, pressure-equalizing, graduated addition funnel, dry ice condenser, and CaCl2 drying tube. Anhydrous HFA (14 mL, 0.12 mol) is collected in the addition funnel and the roundbottom is charged with CH2Cl2 (100 mL) and 90% H2O2 (3.0 mL, 0.11 mol), and then cooled to −60 °C. After dropwise addition of HFA, the mixture is allowed to warm to rt and a clear, homogeneous solution results which can be titrated (NaI, Na2S2O3, ca. 0.7 M) and stored conveniently at −5 °C. Under these conditions, the reagent is stable for at least 2 months. Handling, Storage, and Precautions: slowly decomposes at rt to form CO2, O2, CF3OOH and other products. Hexafluoroacetone is a highly toxic, nonflammable gas and should only be handled in a fume hood. Concentrated solutions of hydrogen peroxide must be handled with care.

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.