Abstract
Antimicrobial activity of benzimidazole type of Fluconazole analogues series were subjected to Quantitative Structure Activity Relationship (QSAR) studies with an effort to derive and understand a correlation between the biological activity as response variable and different molecular descriptors as independent variables. The QSAR results revealed that the presence of methoxy, hydroxy, chloro or fluoro substituents would increase the antimicrobial activity and presence of electron withdrawing groups at R1, R2, R3 and R4 position of benzimidazole ring would increase the activity. Such a theoretical study can help in designing more active molecules than the current ones.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Journal of Nanomedicine & Biotherapeutic Discovery
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
