2D MXene-Integrated 3D-Printing Scaffolds for Augmented Osteosarcoma Phototherapy and Accelerated Tissue Reconstruction.

Shanshan Pan,Luodan Yu,Changqing Zhang,Yu Chen,Junhui Yin,Yufang Zhu,Youshui Gao

doi:10.1002/advs.201901511

Abstract

The residual of malignant tumor cells and lack of bone‐tissue integration are the two critical concerns of bone‐tumor recurrence and surgical failure. In this work, the rational integration of 2D Ti3C2 MXene is reported with 3D‐printing bioactive glass (BG) scaffolds for achieving concurrent bone‐tumor killing by photonic hyperthermia and bone‐tissue regeneration by bioactive scaffolds. The designed composite scaffolds take the unique feature of high photothermal conversion of integrated 2D Ti3C2 MXene for inducing bone‐tumor ablation by near infrared‐triggered photothermal hyperthermia, which has achieved the complete tumor eradication on in vivo bone‐tumor xenografts. Importantly, the rational integration of 2D Ti3C2 MXene is demonstrated to efficiently accelerate the in vivo growth of newborn bone tissue of the composite BG scaffolds. The dual functionality of bone‐tumor killing and bone‐tissue regeneration makes these Ti3C2 MXene‐integrated composite scaffolds highly promising for the treatment of bone tumors, which also substantially broadens the biomedical applications of 2D MXenes in tissue engineering, especially on the treatment of bone tumors.

Highlights

Bone cancer is a general term for malignant bone tumors such as osteosarcoma, chondrosarcoma, and fibrosarcoma.[1]
The dual functionality nately, the invasiveness of cancer as well of bone-tumor killing and bone-tissue regeneration makes these Ti3C2 MXene-integrated composite scaffolds highly promising for the treatment of bone tumors, which substantially broadens the biomedical applications of 2D MXenes in tissue engineering, especially on the treatment of bone as anatomical complexity determines an unattainable radical resection followed by inevitable local recurrence
II, III) TBGS used for osteosarcoma cell elimination by photothermal ablation both in vitro (II) and in vivo (III)

Summary

Introduction

Bone cancer is a general term for malignant bone tumors such as osteosarcoma, chondrosarcoma, and fibrosarcoma.[1]. It is usually divided into autologous skeletal system cancer and bone-metastases cancer bioactive scaffolds. The designed composite scaffolds take the unique The dual functionality nately, the invasiveness of cancer as well of bone-tumor killing and bone-tissue regeneration makes these Ti3C2 MXene-integrated composite scaffolds highly promising for the treatment of bone tumors, which substantially broadens the biomedical applications of 2D MXenes in tissue engineering, especially on the treatment of bone as anatomical complexity determines an unattainable radical resection followed by inevitable local recurrence. University of Shanghai for Science and Technology sition metal atoms, “X” means carbon or nitrogen, and “ene”

Methods

Results

Conclusion