Abstract
A novel glucose sensor was reported that consisted of two-dimensional (2D) Au nanosphere arrays and glucose-responsive hydrogel film. This sensor exhibited an intense diffraction signal and an obvious diffraction color on a quartz slide due to the strong diffraction intensity of the Au nanosphere arrays. Thus, glucose was detected via the variation of diffraction wavelength and diffraction color, without a high reflective mirror. In addition, by introducing poly(vinyl alcohol) (PVA) to crosslink the phenylboronic acid (PBA)-modified hydrogel film, the diffraction wavelength of the 2D Au nanosphere arrays/hydrogel composite film shifted in the same direction in high ionic strength condition. In particular, it showed a nearly linear red-shift when the glucose concentration increased from 0 mM to 20 mM. Moreover, this glucose sensor displayed good reproducibility. The nearly linear response and good reproducibility were highly helpful for improving practical application of this glucose sensor.
Highlights
Diabetes, one of the largest health concerns, has been diagnosed through monitoring the concentration of blood glucose [1,2]
After introducing poly(vinyl alcohol) (PVA) to crosslink the phenylboronic acid (PBA)-modified hydrogel film, the diffraction wavelength of the composite film shifted in the same direction in high ionic strength condition
It showed a nearly linear red-shift when the glucose concentration increased from 0 mM to 20 mM, which is highly helpful for improving practical application of this glucose sensor
Summary
One of the largest health concerns, has been diagnosed through monitoring the concentration of blood glucose [1,2]. A glucose visual sensor was developed by embedding the 2D PS colloidal arrays in a PBA-functionalized hydrogel film [32] In this glucose sensor, besides the rapid preparation process, only one modification step was needed to couple PBAs to the hydrogel matrix. Besides the rapid preparation process, only one modification step was needed to couple PBAs to the hydrogel matrix Both the diffraction measurement and color identification of the 2D array glucose sensor relied on a high reflective mirror due to low reflectivity of PS. After introducing poly(vinyl alcohol) (PVA) to crosslink the PBA-modified hydrogel film, the diffraction wavelength of the composite film shifted in the same direction (red-shift) in high ionic strength condition It showed a nearly linear red-shift when the glucose concentration increased from 0 mM to 20 mM, which is highly helpful for improving practical application of this glucose sensor
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