Abstract
[14812-59-0] C6H12ClO2P (MW 182.58) InChI = 1S/C6H12ClO2P/c1-5(2)6(3,4)9-10(7)8-5/h1-4H3 InChIKey = WGPCXYWWBFBNSS-UHFFFAOYSA-N (reagent used for the phosphitylation of alcohols and other heteroatomic nucleophiles, resulting in the formation of useful glycosyl donors and ligands) Physical Data: bp 81.5–82 °C/13 mm Hg; d 1.149. Solubility: soluble in CHCl3, ether, THF, and most organic solvents. Form Supplied in: colorless liquid, available from Aldrich Chemical Company, Inc. Preparative Methods: the reagent is prepared via the reaction of 2,3-dimethyl-butane-2,3-diol (pinacol) and phosphorous(III) chloride in diethyl ether as solvent with pyridine as base. Other bases such as triethylamine have been used, and yields are moderate.1 Handling, Storage, and Precautions: the reagent is very sensitive to moisture and thus all procedures should be performed under an inert atmosphere. Storage in a sealed container under nitrogen is necessary and, if stored as a solution, the addition of 3A molecular sieves is recommended.
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