Abstract
AbstractIn the course of investigations on structure‐activity relationships of calcium antagonists analogous to fostedil, a series of 2‐aryl‐ and 2‐arylvinyl‐substituted 1,3‐henzothiazoles and 1,3‐benzoxazoles bearing a phosphonate group on the phenyl ring has been synthesized by cyclization, bromination, and subsequent Michaelis‐Arbuzow reaction. Pharmacological investigations on isolated organs from guinea pigs revealed both negative inotropic effects and a relaxing action on smooth musculature; these activities were particularly pronounced in the 1,3‐benzothiazole compound group.
Full Text 
Sign-in/Register to access full text options
Sign-in/Register to access full text options 
Published version (
Free)
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
