Abstract
Mixing two liquids and generating a concentration gradient in a microchannel are important in biochemistry. A concentration gradient is generated by producing a wave-like pattern along the microchannel direction. In this technique, the high frequency vibration of the liquid-liquid interface is generated to form a wave-like pattern for mixing along a short channel length. High frequency switching of the fluid flow is achieved by employing the newly developed microvalve using tailor-made multilayer piezoelectric actuators (TAMPA). This paper details the concept for the concentration gradient generation method. Next, a microvalve (20×15×15 mm) was designed and produced using TAMPA (8.5×10×10 mm). Finally, a concentration gradient in two-layered flow was generated with the microvalve. As a result, the generation of a concentration gradient in two-layered flow with active mixing was achieved in a high-speed fluid (120 mm/s, Re = 14.4). Moreover, the concentration gradient was controlled by adjusting the input voltage to TAMPA.
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