299-POS

Abstract

Objectives The objectives of the study were to analyze the influence of maternal demographic characteristics and uterine artery (UA) Doppler parameters on the occurrence of hypertension. Methods This prospective cohort study included 162 low-risk women with singleton pregnancies and no fetal diseases. Maternal demographic data and UA Doppler parameters were collected prospectively twice, first at 11–14 weeks of gestation and second at 20–24 weeks. The presence of an early diastolic notch in the waveform was noted, and the mean pulsatility and resistance indices were calculated during both intervals. Abnormal UA Doppler study was defined as the presence of bilateral uterine artery diastolic notches and/or a mean pulsatility index or resistance index above the 95th percentile for the gestational age. The primary outcome was the development of hypertension. Chi-square test, receiver operating characteristic curve, and multiple logistic regressions were used for statistical analyses. Results Fifteen (9.25%) women developed a hypertensive disorder. Significant independent prediction of hypertension was provided by mean PI, mean RI, and parity. Parity of two was associated with an increase in risk for the condition (OR 5.9, 95% CI 1.01–34.44, p p p Conclusions First-trimester screening combining maternal factors and UA Doppler indices is useful to predict hypertension in a routine care setting and could be investigated for application of targeted prophylactic strategies. Disclosures A.C. Marcolin: None. R.M. Scandiuzzi: None. S.M. Quintana: None. E.D. Moises: None. R.C. Cavalli: None. G. Duarte: None.