Abstract
Melasma is a hyper-pigmentary disorder with photoaging features. Since the manifestations appear on specific face areas, rich in sebaceous glands, we explored their possible role in the onset. The gene and protein expression of inflammatory and pro-melanogenic factors from the SZ95 sebaceous gland cell line exposed to single or repetitive UVA doses (2 to 8 J/cm2), as triggering stimulus able to reach the dermis and skin appendages, were evaluated. UVA up-modulated the long-lasting production of α-MSH, EDN1, b-FGF, SCF, inflammatory cytokines, and lipid-derived mediators, through the p53 and PPARγ activation, since the interfering significantly reduced the production.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
