Abstract
Annona crassiflora, a fruit from Cerrado, the Brazilian Savanna, has several medicinal uses and antioxidant activity in vitro previously reported, but the underlying mechanisms are unknown. However, any study investigated the effect in vivo of the pulp of A. crassiflora in Alzheimer’s model. Moreover, any study was investigated the in vivo effects of the pulp of A. crassiflora in Alzheimer's model. Therefore, the objective of this study was to analyze the effect of aqueous extract of A. crassiflora (AEAC) against oxidative stress and paralysis (Alzheimer’s model) using the Caenorhabditis elegans model experimental. To induce oxidative stress, wild-type (N2) strains of the worms were exposed to juglone at 250µM for 6 hours. Treatment with AEAC 1000 μg/ml promoted protection of the worms exposed to pro-oxidant agent, showing enhanced survival rates of 32.2% when compared to the control group 5.5 % (p-value
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