Abstract
NUMB plays a crucial role in melanocytic differentiation from multipotent skin stem cells. However, little is known about the role of NUMB in melanoma, although NUMB acts as a tumor suppressor in various human cancer types. Here, we investigated the role of NUMB in melanoma progression and its regulatory mechanism. First, we confirmed that high NUMB expression in melanoma tissues clinically correlates with improved patient survival. Moreover, NUMB expression was downregulated in metastatic melanoma cells compared with primary melanoma cells and normal melanocytes.
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