295 CALCIUM CHANNEL BLOCKERS AND CHANGES OF THE INDICES OF THE BLOOD PRESSURE AND CARDIOHAEMODYNAMICS

Abstract

The aim of this study were to assess the efficacy of the treatment by prolonged dihydropyridine CCB (monotherapy Amlodipine Besylate, 5-10 mg 1 time per day) in patients with EH of the stage II (EHIIst). The study involved 30 patients with EHIIst, their average age was (53.03 ± 1,97) years old. Our results indicate that according to the blood pressure (BP) daily monitoring after 12 weeks of treatment patients with EHIIst showed possible decrease in daily average systolic BP (SBP) (by the data of BP monitoring) by 17,3 mm Hg (p < 0,01), in diastolic BP (DBP) – by 11,2 mm Hg (p < 0,01), in maximum SBP – by 19,4 mm Hg (p < 0,01), in maximum DBP – by 9,2 mm Hg (p < 0,01), in minimum SBP – by 10,9 mm Hg (p < 0,01), in minimum DBP – by 8.6 mm Hg (p < 0,01). From 13 (43,3%) patients with initially low night decrease in BP (daily index is less than 10%), 10 (33,3%) patients recovered the daily index of 10-20%. When analyzing the dynamics of the indices of transmitral blood flow (by Doppler-Echocardiography) positive changes indicating the improvement of left ventricular diastolic function were detected: isovolumic relaxation time (IVRT) changed – on the 12th week of the treatment the decrease in IVRT was at the average (7,8 ± 2,35) ms (8,2%) (p < 0,01), the ratio between early (E) and late (A) left ventricular diastolic filling velocity (E/A) increased from (0,73 + 0,02) to (0,79 + 0,02) (p < 0,01). Thus, monotherapy by prolonged dihydropyridine CCB in the treatment of patients with EHIIst contributes to the possible decrease in the average, maximum and minimum SBP and DBP when it is monitored daily, helps to recover the decreased daily index of BP and improves diastolic function of the left ventricle.