Abstract
IGF2BP1 is a multifunctional RNA-binding protein that regulates the stability, localization and translation of its mRNA targets. High levels of IGF2BP1 expression have been shown to be associated with poor prognosis in patients with variety of cancer types. Given the correlation between elevated IGF2BP1 expression and poor clinical outcomes, the specific activation of IGF2BP paralogs in a wide variety of cancers, and the effectiveness of preventing metastasis in animal models by reducing IGF2BP1 activity, therapies directed at inhibiting IGF2BP1 function constitute a potentially powerful approach for fighting cancer.
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