Abstract
Publisher Summary This chapter provides an overview of soluble immune response suppressor (SIRS). The lymphokine SIRS is a protein which exists as two species of 14,000 and 21,000 daltons and is produced by suppressor T lymphocytes. SIRS is activated or oxidized to SIRS ox by macrophages in an H 2 0 2 -mediated reaction. SIRS ox activity was originally referred to as macrophage-derived suppressor factor before the relationship between SIRS and SIRS ox . The chapter further explains preparation of SIRS OX . Activated SIRS or SIRS ox can be obtained from three sources: (1) reaction of SIRS with H 2 0 2 , (2) culturing SIRS with splenic adherent cells, or (3) culturing SIRS with the macrophage like cell line RAW264.The most important component governing production of SIRS ox from the reaction of SIRS with H 2 0 2 appears to be the presence of contaminating proteins in the SIRS preparation.
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