Abstract
Previous investigations using plasma IGF-I in children with growth hormone deficiency (GHD) as a predictor of the response to growth hormone treatment have given variable and usually negative results. When the growth response to the first year of growth hormone treatment (0.1 mg/kg TIW) was compared to pretreatment plasma IGF-I values measured after acid chromatography (AC) in a group of 72 children with classic GHD, a correlation of -0.67 (p <0.001) was obtained. In a subgroup of 33 of these children, we were able to compare IGF-I RIA after AC to direct plasma assay using a commercial kit to measure IGF-I. With both RIA's, the IGF-I values in these GHD patients were generally below the normal range. The correlations obtained in the 33 patients with GHD between the growth rate in the first year of GH treatment and these two IGF-I RIA's were -0.07 (NS) for the direct RIA, and -0.65 (p <0.001) for AC. These results stress the importance of AC in the measurement of IGF-I, and show that properly performed, IGF-I is the strongest single predictor of response to GH treatment in GHD children.
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