Abstract
Publisher Summary The biologic features of the murine B-1 cell are similar to the proliferative B-1 cells in human chronic lymphocytic leukemia (CLL), particularly the subset of CLL known as Richter's syndrome. The biologic similarities between human CLL and the B-1 cell malignancy in NZB mice and their shared dependence on IL-10 as a growth factor suggest that the NZB mouse neoplasm may be a model for human CLL and that antisense IL-10 may have some clinical utility in the treatment of CLL. Salient features of the major components of this study are summarized in this chapter. The studies described in the chapter indicate that (interleukin 10) IL-10 mRNA antisense oligonucleotides can negatively influence the progression of experimentally transplanted B-1 cell malignancies in (NZB × DBA/2) Fa mice.
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