Abstract
In a prospective study of 23.822 newborns (NB) at the Hospital E. Deformes, Valparaiso, between 1/1/73 and 12/31/77, 31 cases (15 males and 16 females) were diagnosed as Down Syndrome (DS). The incidence was 1/768 NB. Average maternal age in DS was 29.39 years (s.d. 9.93) while in mothers with normal offspring it was 24.67 years (s.d. 6.36). Distribution and incidence related to maternal age are shown in table: The relationship between advanced maternal age and DS is well known. There is a strinkingly increased risk in very young mothers Despite the small size of the sample, this study permits the device of risk tables with short age intervals, useful in genetic counseling.
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