Abstract
Lung TRACERx is a prominent study employing multi-region and longitudinal multi-omics sequencing to unravel the evolutionary trajectories of cancer. Although aberrant DNA methylation patterns have been widely described in nearly all human cancers, their interplay with genomic alterations in lung cancer is poorly understood. Incorporating the contribution of epigenetic modifications to cancer evolution trajectories within TRACERx could improve our understanding of the intricate relationship between genetic and epigenetic modifications.
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