Abstract
Deregulated lipogenesis is essential for tumor cell survival. Regardless of circulating lipid levels, a wide range of tumors presents accelerated de novo fatty acid synthesis. Oncogenic lipogenesis is manifested by enhanced activity and coordinated expression of multiple lipogenic enzymes including ATP-citrate lyase (ACLY) in tumor cells. Therefore, the present study was aimed at understanding the influence of ACLY on breast tumorigenesis and its role in inducing immune escape.
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Schedule a callMore From: Annals of oncology : official journal of the European Society for Medical Oncology
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