Abstract
Neurofibromatosis 1 (NF1) is one of the most common genodermatoses and cutaneous neurofibromas (cNFs) manifest in almost every adult with NF1. The immune microenvironment of cNFs is incompletely known. A total of 60 cNFs from ten patients with NF1 were used for immunolabeling. Tumor T-cells were visualized and counted based on positive reaction for CD3, CD4, CD8 and FoxP3. CD68 and CD163 were used to detect macrophages. The aggregation of cells at the tumor margin was separately assessed for the topmost part of the tumor covered by epidermis.
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