288 Prevalence of associated lipid abnormalities in high-risk French patients treated with statins – The DYSIS study

Abstract

Purpose Although statins are the cornerstone of cardiovascular (CV) prevention, patients (pts) treated with statins remain at substantial CV risk. Persistent lipid abnormalities, among other CV risk factors (RF), are likely to contribute to this residual CV risk. The objective of the study was to assess the prevalence of dyslipidemia in high-risk pts receiving statin therapy. Methods This French cross-sectional study was conducted by 741 general practitioners or specialists within the international DYSIS study performed in 12 countries (Europe, Canada). Pts were ≥45 years-old, on statin therapy for ≥3 months with available lipid values. A clinical examination and the recording of the latest lipid values on statin were performed. High-risk pts included pts with CV disease, or pts with diabetes and 2 or more RF or patients with a 10 years risk of coronary event > 20%. Results Among 4335 pts included in DYSIS, 2669 (61.6%) were at high risk. Data for this group of pts are presented hereafter. Their mean age was 66.9 ± 9.8 years, 72.6% were male, 78.6% had hypertension, 48.2% had diabetes, 29.9% had family history of premature CV disease and 13.3% were smokers. CHD was present in 55.1% of pts, cerebrovascular disease in 12.2% and peripheral artery disease in 21.7%. 30.5% were obese and 66.7% had metabolic syndrome. Conclusion Persistent dyslipidemia is still prevalent in high risk statin-treated pts in France, with high proportions of pts not at LDL-C goal with low HDL-C and/or elevated triglycerides. An intensive and comprehensive lipid management in this population would decrease the prevalence of lipid abnormalities and might contribute to further decrease the CV risk. Table. Percentage of high risk statin-treated pts with different lipid abnormalities (n=2669) LDL-C not at goal (> 1 g/l) Low HDL-C ( Elevated TG (>1.5 g/l) LDL-C not at goal + HDL-C 1.5 g/l High CV risk pts (%) 52.4 23.0 38.2 25.7