288 Multitarget Stool DNA Testing Is for Everyone: Positive Findings in Different Racial Groups

Abstract

INTRODUCTION: Different ethnic/racial groups may have unique incidences of colorectal cancer with some groups being at higher risk than others. Our study aims to look at outcomes of multitarget stool DNA testing in different racial groups. METHODS: There were 19400 patients who had multitarget stool DNA tests ordered. Baseline demographic traits were recorded. Of these, 1413 positive stool DNA tests followed by documented subsequent colonoscopy. A total of 12 patients with unknown racial group/ethnicity, unknown indication and findings of other carcinoma other than adenocarcinoma were excluded from analysis. Only the index lesion was recorded. Advanced adenoma was defined as an adenoma that is larger than 10 mm or had high risk features such as villous transformation or high grade dysplasia. Nonadvanced adenoma was defined as an adenoma that is smaller than 10 mm and had no high risk features. Racial/ethnic groups were divided into white/Caucasian and non-white. Statistical analysis with Chi-square was done to compare the proportions. A P-value < 0.05 was considered statistically significant. RESULTS: Of the patients who had multitarget stool DNA tests ordered, 206 (1.06%) were of Hispanic origin, 53 (0.27%) American Indian or Alaskan Native, 242 (1.25%) Asian, 1131 (5.83%) African American/Black, 1 (0.01%) Native Hawaiian, 5 (0.03%) Other Pacific Islander, 17416 (89.77%) Caucasian/White and 346 (1.78%) of unknown/unreported backgrounds. A total of 1401 patients were analyzed. For the white/Caucasian cohort, 1353 (75.54%) had subsequent colonoscopy compared to 97 (75.19%) of the non-white group (P = 0.93). Adenocarcinoma cases were 22 (1.68%) in white patients versus 2 (2.17%) in the nonwhite group (P = 0.67), advanced adenomas were 401 (30.68%) versus 30 (32.61%) (P = 0.70), nonadvanced adenoma was 388 (29.69%) versus 26 (28.26%) (P = 0.77), and no adenoma was 496 (37.95%) versus 34 (36.96%) (P = 0.85), respectively. CONCLUSION: From our study, there is no difference in colonoscopy findings from positive multitarget stool DNA tests between racial groups nor is there a difference in adherence to follow-up colonoscopy. Our study is limited by the number of patients within minority groups.