Abstract

Vitiligo is an acquired chronic depigmentation disorder characterized by progressive depigmentation due to the destruction of epidermal melanocytes. The dysfunction of melanocytes plays an important role in the pathogenesis of vitiligo. In this study, we found that secreted frizzled-related protein 5 (SFRP5) is overexpressed in the skin lesions of vitiligo patients. Compared with normal epidermal melanocytes (PIG1), the expression of SFRP5 is increased in vitiligo melanocytes (PIG3V). To investigate the effect of SFRP5 on melanin synthesis, PIG1 cells were infected with recombinant SFRP5 adenovirus (AdSFRP5), and PIG3V cells were infected with recombinant siSFRP5 adenovirus (AdsiSFRP5).

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