Abstract
It is known that ultraviolet B (UVB) radiation causes skin disorders by oxidative stress. Recent studies have shown that fermentation forms a deformable chemical structure or creates new substances in fish oil. In this study, we investigated whether mackerel fermented fish oil (FFO) has protective effects against UVB-induced oxidative stress in human keratinocyte (HaCaT) cells. As a result, FFO showed no intracellular toxicity and had directly super oxide radicals and hydroxyl radicals scavenging ability. In addition, FFO showed anti-oxidative cytoprotective effect by removing intracellular reactive oxygen species (ROS) induced by UVB. UVB-induced oxidative deformation, including lipid peroxidation, protein carbonylation and DNA damage were weakened in treated FFO cells. FFO also reduced UVB-induced apoptosis such as apoptotic bodies, DNA fragmentation, caspase activation and increased pro-apoptotic Bax expression. On the other hand, FFO increased antioxidant protein expression such as anti-apoptotic Bcl-2. Overall, these results demonstrate that FFO protects HaCaT cells from UVB-induced oxidative stress through the ROS removal effect. (2016H1D5A1908786)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
