Abstract
Genetic effects play a role in hand eczema (HE), according to population-based twin and candidate gene studies. However, the genetic factors responsible for HE are not fully understood. Therefore, the aim of this study was to identify and characterize genetic loci associated with HE in Lifelines, a Dutch general population-based prospective cohort and biobank study. The primary analysis consisted of 2.789 cases with self-reported HE and 12.316 healthy controls without self-reported HE, eczema, atopic dermatitis (AD) and/or contact allergy.
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