283 Effect of moderate wine consumption on high density lipoprotein-cholesterol levels in high risk patients: A prospective observational study

Abstract

Regular light to-moderate wine consumption, defined as 1-3 drinks/day, is associated with a lower risk of cardiovascular disease. Moreover, half of the cardiovascular benefit of wine consumption would be attributable to its High density lipoprotein-cholesterol (HDL-C) rising effect. The aim of this prospective study was to investigate the association between moderate wine consumption and HDL-C levels in patients who survived an acute myocardial infarction (AMI). From the French regional RICO survey, 920 consecutive patients surviving an AMI were included between the 1 st January and the 31 st december 2005. At one year follow-up, patients were asked to report their wine consumption, using a questionnaire and examination of serum lipids was performed. Associations of demographic, clinical, and lifestyle risk-factors with HDL-C levels were assessed with multivariate analysis. Patient consuming 1-3 drink/day of wine had higher HDL-C levels (respectively, 0.47(0.38-0.56) vs 0.43(0.35-0.53) mg/dL, (p=0.026)), and lower CRP concentrations (2(1-5) vs 4(2-7) mg/L (p=0.01)), than non or high-drinkers (0 or >4 drink/day). No difference was reported for triglycerides or LDL-C levels in the two groups. In univariate analyses, CRP levels, diabetes, smoking and body mass index (BMI) were negatively associated with high HDL-C (> 40 mg/dL in men and >50 mg/dL in women). In contrast, female, physical activity and moderate wine intake were positively associated with HDL-C. In multivariate analyses, BMI (OR (95%CI) (0.91(0.87-0.96)), physical activity (OR(95%CI) (1.23(1.07-1.41)) and moderate wine intake (OR(95%CI) (1.84(1.22-3.73)) were associated with high HDL-C. These data suggest that a moderate wine intake is associated with elevated levels HDL-C levels. This association may participate to the beneficial effect of moderate wine intake on cardiovascular disease.