Abstract
Ultraviolet radiation (UVR) exposure is associated with increased risk of skin cancer. However, mixed evidence suggests a protective, inverse relationship between UVR and risk of certain non-cutaneous cancers, depending on temporality of exposure. To address this discrepancy, we examined three ongoing U.S. prospective cohort studies, the Health Professionals Follow-Up Study (HPFS) and Nurses’ Health Study (NHS) I and II, to identify associations between cumulative UV exposure and cancer risk. We used an established spatiotemporal exposure model to calculate cumulative time-varying average UV exposure, defined as average July noon-time erythemal UVR.
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