(282) - Coagulation Factors Abnormalities in LVAD Patients with Anti-Factor 10a and PTT Discordance

Abstract

survival and freedom from GI bleed and hemorrhagic stroke were calculated using the Kaplan-Meier method. Association of GI bleeding, hemorrhagic stroke and survival were analyzed as a time-dependent covariate. Results: Median follow-up was 12.4 year (max, 11 years, total 1,757 patientyears of support). Freedom from GI bleeding was 81% at 1 year, 74% at 3 years and 71% at 5 years. Freedom from hemorrhagic stroke was 96% at 1 year, 92% at 3 years and 87% at 5 years. When analyzed as a time-dependent covariate, an episode of GI bleeding did not predict subsequent risk of hemorrhagic stroke (H.R.: 0.42, [0.15, 1.17], p= 0.095). Overall survival was 83% at 1 year, 60% at 3 years and 43% at 5 years. When analyzed as a time-dependent covariate, both hemorrhagic stroke and GI bleeding adversely affected late survival (HR: 4.9 [3.16, 7.5], p= 0.001) and (HR: 0.1.59 [1.2, 2.1], p< 0.001). Conclusion: In this large, multi-institutional analysis, we did not identify a relationship between GI bleeding and subsequent risk of hemorrhagic stroke. However, the development of either of these adverse events did negatively affect late survival. Understanding the relationship of adverse events after LVAD enhances approach to their management.