28140 How a lotion with prebiotic yeast extract regulates the environmental aggressors impact on the skin microbiome

Abstract

Environmental aggressors cause skin damage and have been conjectured to modulate the skin microbiome. An 8-week clinical study (N = 100) and an ex vivo pollution simulation study were conducted to explore the profile of consumer lifestyle-based aggressor exposure and its impact on skin. The application of a topical lotion with prebiotic yeast extract was tested for the ability to perform as a preventive and restorative solution. Clinical study results indicated that continuous light pollution exposure (PM2.5 <100) significantly correlated with higher TEWL and lower moisture. Ex vivo pollution simulation study showed a decreased expression of caspase-14, a skin barrier biomarker, further indicating that the skin barrier becomes less resilient in harsh city environment. Although the microbiome diversity on healthy subjects’ skin was stable, the harsh city environment resulted in a significantly lower richness (Chao1) compared with baseline, indicating a change in low abundant species. As a solution to the change in microbiome richness, the application of topical lotion with prebiotic yeast extract over 8 weeks can boost growth of skin commensal bacteria and maintain microbiome richness. In addition, dominant bacterium counts were significantly increased, with 10 more dominant bacteria including a detox bacterium that metabolizes polycyclic aromatic hydrocarbons (PAHs), a major pollutant. In conclusion, an individual’s residential environment and lifestyle have a significant impact on the skin microenvironment. The use of a topical lotion with prebiotic yeast extract regulate skin microbiome balance by boosting the growth of beneficial bacteria, thereby preventing and restoring the impact of daily aggressors on the skin.