Abstract
Symptomatic or asymptomatic peripheral artery disease (PAD) is a strong marker of cardiovascular events and Death. The prevalence of PAD is well documented in a high-risk subset, but less information is available in patients with moderate or intermediate CV risk. To assess the prevalence of asymptomatic PAD defined as an ABI≤0.9 in subjects with moderate cardiovascular (CV) risk. PANDORA is a multicentre, international, cross-sectional observational study performed in primary care. ABI measurement was performed in subjects with > 2 CV risk factors (RF) with no overt vascular disease nor diabetes mellitus. Among 10287 subjects in Europe, 1011 were included in France. The mean age is 65 yrs (males 55%). ABI≤0.9 was found in 12.2% (95%CI [10.1;14.2]). Mean LDL-cholesterol was 1.29 g/L. Results for RF association (Logistic regression) are shown in table 1. Table. Chi 2 p-value OR 95%CI Age 0.705 1.004 0.982-1.027 Gender (male vs female) 0.982 1.006 0.600-1.686 BMI 0.325 0.972 0.916-1.029 Family history of premature CHD (yes vs no) 0.744 1.133 0.534-2.405 HDL-C (low vs not low) 0.898 1.039 0.577-1.872 LDL-C (High vs not high) 0.427 0.847 0.562-1.276 Sitting BP (hypertension vs normal BP) 0.071 1.598 0.961-2.657 Smoking status (Habitual smoker vs non-smoker) 0.012 2.017 1.166-3.489 Physical activity (inactive vs active) 0.0003 2.144 1.414-3.250 Alcohol (high intake vs no intake) 0.845 0.927 0.433-1.984 Statin treatment (Treated vs Untreated) 0.101 0.601 0.329-1.104 In the Pandora study, the prevalence of asymptomatic PAD among subjects with moderate CV risk in France is 12.2%, strongly related to smoking and low physical activity. In patients with moderate CV risk, detection of asymptomatic PAD and management of modifiable RF such as smoking and physical activity could improve the overall CV risk. PANDORA Study was sponsored by AstraZeneca.
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