Abstract
Engineered heart tissue patches might provide a future option for the therapy of terminal heart failure. Recent advantages in stem cell biology allow the generation of large numbers of human induced pluripotent stem cell derived cardiomyocytes (hiPS-CM). Here we investigated if human iPS-cell derived engineered heart tissue (hEHT) grafts support left ventricular function in infarcted hearts of guinea pigs, a species with a relatively human-like cardiac physiology.
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