(281) Does Intravenous Nalbuphine Decrease Urinary Retention Caused by Intrathecal Morphine? A Randomized Controlled Trial

Abstract

Opioids are commonly used as analgesics during the perioperative period . Morphine is the standard opioid analgesic for pain control, however many patients may shift to an alternative opioid because of its intolerable adverse effects. 60 Patients randomly allocated as follows: group 1: received standard intrathecal dose of 2.5 ml of 0.5% bupivacaine in 8% dextrose and intravenous 0.9% saline solution (placebo),3ml every 6 hours for 24 hours group 2: received 0.15 mg of intrathecal morphine plus standard intrathecal dose of 2.5 ml of 0.5% bupivacaine in 8% dextrose and intravenous 0.9% saline solution (placebo), 3ml every 6 hours for 24 hours . group 3: received 0.15 mg of intrathecal morphine plus standard intrathecal dose of 2.5 ml of 0.5% bupivacaine in 8% dextrose and intravenous nalbuphine, 3mg every 6 hours for 24 hours. Groups 2 and 3 had significantly more itching and vomiting than group 1 (p . value 0.001). Groups 2 and 3 did not differ from group 1 in urinary retention, sedation and respiratory depression. Groups 2 and 3 had better analgesia and satisfaction than group 1 (p. value 0.001). Groups 2 and 3 did not differ regarding pain, itching, vomiting, urinary retention, sedation and respiratory depression. Group 3 had better satisfaction when compared to group 2 (p-value