Abstract
Melanomas are often easy to recognize clinically but determining whether a melanoma is in situ (MIS) or invasive is often more challenging even with the aid of dermoscopy. During the past five years, convolutional neural networks (CNNs) have made significant and rapid advances within dermatology image analysis. The aims of this investigation were to create a de novo CNN for differentiating between MIS and invasive melanomas based on clinical close-up images and to compare its performance on a test set to seven dermatologists.
Highlights
Utility of serum S100B in melanoma patients EA Janka1, T Varvolgyi1, Z Sipos2, A Soos2, P Hegyi2, S Kiss2, F Dembrovszky2, M Solymar2 and G Emri1 1 Department of Dermatology Faculty of Medicine, University of Debrecen, Debrecen, Hungary and 2 Institute for Translational Medicine, Medical School, University of Pecs, Pecs, Hungary According to the Globocan 2020 statistics the age-standardized mortality rate of melanoma is still high
Switzerland, 2 Department of Dermatology, University Hospital Tuebingen, Tuebingen, Germany, 3 Department of Dermatology, Medical Faculty and University Hospital Carl Gustav Carus, TU Dresden, Dresden, Germany, 4 Skin Cancer Center, Department of Dermatology, University Hospital Hamburg-Eppendorf (UKE), Hamburg, Germany, 5 Department of Dermatology, University Medical Center Mainz, Mainz, Germany and 6 Department of Dermatology, Medical University of Graz, Graz, Austria This study addressed the prognostic impact of distinct patterns of metastasis and its relevance for individual target lesions (TLs) in advanced melanoma patients
Serum tumor markers can be useful for early detection of tumor metastases, there is no consensus on the utility of blood tests for patients with resected melanoma
Summary
To investigate the impact of stimulated MCs on tumor progression and immune cell recruitment, in vivo studies with mastcell deficient Mctp5-Cre RDTA mice are performed. Viable probiotic strains demonstrate to inhibit S. aureus growth; interestingly, PFSNs alone (both from single and co-cultured strains) act in reducing pathogen plankton viability and in inducing phenotypic changes. S. aureus over-colonization, crucial factor in the onset and progression of several skin diseases, could be reduced by both viable Lactobacilli and their PFSNs. The deeper investigation of the cross-talk among microbes will help in clarifying their role in several cutaneous disorders.
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