Abstract
Observational studies have led to speculation that antenatal vitamin D supplementation may reduce the risk of offspring atopic eczema, but currently there are no proven general population preventive interventions. In the Maternal Vitamin D Osteoporosis Study double-blind, randomized, placebo-controlled trial, we examined the link between maternal supplementation (from 14 weeks’ gestation until delivery) with cholecalciferol 1000 IU/day or matched placebo with offspring atopic eczema risk at age 12 months (n=636), ascertained based on the UK Working Party Criteria for the Definition of Atopic Dermatitis.
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