Abstract
Introduction: Hyaluronic acid (HA) chains readily degrade under crosslinking conditions employed to stabilize HA for aesthetic use. Different manufacturing technologies result in fillers that significantly vary in HA chain integrity, which may impact clinical performance and safety of products in situ. HA fragments generated during the manufacturing process are extractable as a soluble HA (sHA) fraction. This study examined sHA chain length and distribution in commercial filler products to understand the impact of filler manufacturing technologies on HA chain degradation.
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