Abstract
Malignant tumors of the liver are among the most common causes of cancer-related death throughout the world. Current therapeutic approaches fail to control the disease in most cases. This study seeks to explore the therapeutic potential of transcriptional regulatory sequences of the imprinted genes H19 and Insulin growth factor 2 (IGF-2) by directing tumor-selective expression of a toxin gene (A fragment of diphtheria toxin), delivered by non-viral vectors.
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