280 Sleep in children with cystic fibrosis. A questionnaire-based case–control study

Abstract

Background Adult cystic fibrosis (CF) patients with severe lung disease are known to have an impaired neurocognitive function and daytime sleepiness. They reported significantly more daytime sleepiness and poorer sleep quality due to chronic sleep loss and nocturnal hypoxaemia. It is speculated that sleep disruption in CF children may have an impact on quality of life and clinical outcomes. Literature on sleep disturbances in children with CF is scarce without comparison to healthy controls. Aim Investigate the sleep quality using a sleep disturbance questionnaire (SDQC, Bruni et al 1996) in CF children in relation to the Body Mass Index (BMI), overnight tube feeding and pulmonary function. Compare the results of the SDQC with siblings and healthy controls. Method A SDQC was taken from parents of school aged CF patients (2.5–18 years), and also for each sibling and gender and age matched controls. BMI z-score, length z-score, use of overnight tube feeding and pulmonary function (Jaeger Masterscreen Body) (FEV1%, FVC%) were recovered from the CF medical file. Results The inclusions are still going on. Until now 25 CF patients, 12 siblings and 43 controls are already participating. Recruitment will go on until the end of February. Conclusion Whether the presence of sleep disturbances is significantly more common in children with CF compared to their siblings and healthy children. The relation between the sleep characteristics and pulmonary function, nutritional state or nocturnal feeding will be highlighted. Furthermore, by comparing the results of the SDQC with those of the siblings and healthy control children, family context as a bias might be avoided.