Abstract
Chronic itch is one of the most frequently reported symptoms in patients with epidermolysis bullosa (EB). We hypothesized that a neurokinin-1 receptor antagonist (NK1RA) which targets the substance P pathway can reduce EB-related itch. In 2019, we reported on the safety of a NK1R antagonist, serlopitant, in a pilot study. Here we report the phase 2 randomized, double-blind, placebo-controlled trial evaluating serlopitant 5mg PO daily for 8 weeks versus placebo for EB-related pruritus. The double-blind phase was followed by a 4-week washout and optional open label extension.
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