Abstract
Abnormalities in thyroid function have been reported in chronic liver disease (CLD). Wa studied 19 patients (P), 12 boys & 7 girls, aged 1.2–13.6 years (median 7.5) divided in 3 groups (G): Gl, 9P with CLD with a prothrombin time (PT) > 50%; G2, 7P with PT < 50%; G3, 7P who had received arthotopic liver transplantation (CLT) 2-19 months before (4 were also studied pre OLT). Statistics were performed by analysis of variance & Tukey test. Results are shown in the table:TSH levels did not show any significant variation. PT was correlated (p<0.05) with Alb, T3, T4, fT4, IGF-I. Alb was correlated with T3, T4, fT4, IGF-I. In G2, 5P died 8–70 days after the study & the remaining 2P received an CLT after 58 & 76 days with favorable cutcome. In Gl, 4P received CLT after 5–18 months. In conclusion, we have found a correlation between thyroid & liver dysfunction; the presence of PT 50% & decreased thyroid hormone levels indicate an immediate disfavorable outcome. IGFI levels increased after CLT.
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