Abstract
The 27th annual GP2A (Groupement des Pharmacochimistes de l′Arc Atlantique/Group of Medicinal Chemists in the Atlantic Arc) conference took place from 21 to 23 August 2019, at the East Midlands Conference Centre (University Park, Nottingham, United Kingdom) and was hosted by the Division of Biomolecular Science and Medicinal Chemistry (BSMC), within the School of Pharmacy at the University of Nottingham. The event brought together an international delegation of researchers with interests in medicinal chemistry and interfacing disciplines. In addition, a pre-conference workshop provided an opportunity for younger researchers to develop their theoretical knowledge in quantitative pharmacology. s of presentations by the 14 invited speakers and 6 young researchers, in addition to 41 posters, are included in this report.
Highlights
The GP2A (Groupement des Pharmacochimistes de l Arc Atlantique/Group of Medicinal Chemists in the Atlantic Arc) network is made up of researchers in the field of medicinal chemistry working in universities and research institutes across Europe
In order to make these tasks as accurate as possible, it is critical to define quantitative, system independent measures of compound action. This workshop will introduce the concept of quantitative molecular pharmacology and detail the experimental and analytical methods used to determine key system-independent pharmacological descriptors of both drug binding and functional efficacy
GPCR crystal structures may leverage an effective development of novel drug candidates because they can be used for structure-based in silico docking screens, giving access to new chemotypes and, as a consequence, to new biological profiles
Summary
The GP2A (Groupement des Pharmacochimistes de l Arc Atlantique/Group of Medicinal Chemists in the Atlantic Arc) network is made up of researchers in the field of medicinal chemistry working in universities and research institutes across Europe. It was founded in 1992 with the aim of bringing together researchers to exchange ideas and expertise and facilitate a friendly collaborative networking environment. It has included members from France, Spain, Portugal, Ireland and the United Kingdom (the “Atlantic Arc”). These included infectious and neurodegenerative diseases, chemoprevention of cancer, approaches to target identification, hit identification and optimisation for drug candidates, natural products, inflammatory diseases/pain and the application of structural cheminformatics
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