279 The use of PRP to target dysregulated pathways in androgenetic alopecia

Abstract

Androgenetic alopecia (AGA) is the most common type of progressive hair loss; however, its treatment remains limited in scope, thus driving the need for alternative therapies for hair restoration. The pathogenesis of androgenetic alopecia is not completely understood but involves disruption of the Wnt/β-catenin signaling pathway, resulting in premature termination of the anagen growth phase in hair follicles. This manifests clinically as the transformation of terminal hair into thinner vellus-like hair, a process known as hair follicle miniaturization.