279: Maternal serum A1C levels and triglycerides as predictive factors for LGA newborns in type 1 diabetic women

Abstract

279 Maternal serum A1C levels and triglycerides s predictive factors for LGA newborns in ype 1 diabetic women Elena Ciriello, Luisa Patane, Serena Pirola, Santa Barresi, iorgia Cavalli, Nicola Strobelt, Luigi Frigerio, Alessandro oberto Dodesini, Roberto Trevisan Ospedali Riuniti, Obstetrics and Gynecology, Bergamo, Italy, Ospedali Riuniti, Diabetology, Bergamo, Italy OBJECTIVE: The aim of the present study was to determine the role of etabolic maternal parameters in predicting large for gestational age LGA) neonates of women with type 1 diabetes mellitus (T1DM). STUDY DESIGN: We conducted a retrospective cohort study of a group of singleton pregnancy with T1DM who delivered in our hospital from June 2004 and June 2012. We compared maternal and fetal outcomes of women who delivered LGA with ones who had AGA newborns. Statistical analysis was performed with Fisher and T-test. RESULTS: A total of 80 women with T1DM delivered during the study eriod. Fifty-four (67%) women had AGA and 26 (33%) LGA babies. o differencies were found in maternal characteristics (maternal age, MI, duration of diabetes, pre-pregnancy diabetic complications, arity) in the study population. Metabolic parameters were evaluated onthly since 5th to 36th week. No significant correlations were ound between LGA rate and maternal total cholesterol or HDL choesterol levels and uric acid. Maternal A1C levels and fasting serum riglyceride were significantly higher in the second and in the third rimester in LGA group compared with other mothers (Table). CONCLUSION: These observations are in accordance with other reports and suggest that there is an association between A1C levels and heavier neonates in T1DM women. Maternal triglycerids may be considered a new predictor of neonatal birthweight. Lipid levels throughout pregnancy and their association need to be studied in women with type 1 diabetes mellitus.