Abstract
Background: Hypoxia inducible factor-1 (HIF-1), a transcription factor regulating cellular adaption to low oxygen levels, supports anaerobic ATP generation in eukaryotic cells. It has been implicated in prevention of premature cellular senescence and pathogenesis of aging-related diseases. HIF-1 also plays a role in host defense, promoting bactericidal activity and supporting innate immune activities. Further, aging decreases SIRT-1 levels, attenuating mitochondrial biogenesis and causing aging-related diseases. Overexpression of SIRT-1 promotes mitochondrial biogenesis and subsequent activation of HIF-1α. Bakuchiol (Sytenol A) has shown to be a natural alternative to retinol, modulating multiple retinol and non-retinol targets.
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