276 Treatment results and prognostic factors for radiotherapy of pituitary adenomas

Abstract

Purpose Analysis of prognostic factors and evaluation of long-term results of pituitary adenomas radiotherapy. Methods and Materials The study involved 85 patients with pituitary adenomas treated with radiotherapy alone (17 pts) and post-operative radiotherapy (68 pts) in the Centre of Oncology, M. Sklodowska-Curie Memorial Institute, Gliwice, Poland, between 1980 and 1989. The median total dose was 50 Gy given 5 days a week with fraction size of 2 Gy. Univariate and multivariate analyses of 17 possible prognostic factors were performed. Results The 5-year actuarial survival was 95% (90.5% for the patients given radiotherapy alone and 100% for the patients treated with surgery and post-operative radiation). The 10-year actuarial survival for the group of 35 patients was 91% (100% and 71% respectively). The 5-year disease free survival was 73%. The 10-year disease free survival was 68%. The analyses of prognostic factors revealed that none of 17 possible factors significantly predict treatment outcome. No radiotherapy related complications were found in the study group. Conclusion Both radiotherapy alone and post-operative radiotherapy are safe and effective in the treatment of pituitary adenomas.