275P A phase II study of LAG525 in combination with spartalizumab (PDR001), PDR001 and carboplatin (Carbo), or Carbo, as first- or second-line therapy in patients (Pts) with advanced (Adv) triple-negative breast cancer (tnbc)

Abstract

In TNBC, despite high initial response to chemotherapy (CT), many pts relapse, and options for treating recurrence are limited. Combining immunotherapy and CT may synergise to enhance therapeutic efficacy. Here we evaluate LAG525, an anti-LAG-3 antibody (ab), with PDR001, an anti-PD-1 ab, and/or carbo in pts with adv TNBC.