Abstract
Atopic eczema is a complex trait caused by the interaction of multiple genetic and environmental factors. DNA methylation is an epigenetic modification involved in gene regulation that is also influenced by genes and the environment. We aimed to determine if methylation patterns are associated with an eczema diagnosis in a population-based cohort. Blood-based genome-wide DNA methylation data were obtained for 1341 individuals from the Generation Scotland cohort, a family-structured, population-based cohort of 20,000 individuals aged 18-99 years from across Scotland, UK.
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